AG Tobias Madl - Structural Biology of Signal Transduction
Our research focuses on structural biology of signal transduction. One of our major interests are the general mechanisms by which transcription factors are acting as key regulators of cell and organismal fate, and how they contribute to diseases and ageing. Transcription factors are at the heart of signaling cascades and tightly regulated by a plethora of co-factors and post-translational modifications. Our focus is on transcription factors that link the regulatory Wnt pathway with insulin/growth factor signaling and oxygen metabolism. We study the involved dynamic transcription factor – co-factor complexes and the modulation of the interactions by post-translational modifications and disease mutations.
To this end we employ and develop an integrated structure determination protocol in which we combine Nuclear Magnetic Resonance (NMR) spectroscopy, Small-angle X-ray/neutron scattering (SAXS/SANS) and modeling strategies which are especially suited to study the structure of large and dynamic protein complexes.
Another research topic of our group is the molecular mechanisms of signal transfer mediated by disordered proteins. Distortions in signal transduction lead to a plethora of diseases (i.e. cancer and neurodegenerative disorders) and are linked to ageing. We aim to reveal the molecular mechanisms underlying interactions of disordered proteins to provide insight into the intricate link between their function, regulation and human diseases.
We are associated with the groups of Prof. Michael Sattler and Prof. Bernd Reif. The group is integrated into the Bavarian NMR Center, and associated with the Institute of Structural Biology at the Helmholtz-Zentrum München.